Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY) of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In this study we present a detailed contribution of...

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Bibliografski detalji
Izdano u:Haematologica
Glavni autori: Graça, Nuno A. G., Ercig, Bogac, Pereira, Leydi Carolina Velásquez, Kangro, Kadri, Kaijen, Paul, Nicolaes, Gerry A. F., Veyradier, Agnès, Coppo, Paul, Vanhoorelbeke, Karen, Männik, Andres, Voorberg, Jan
Format: Artigo
Jezik:Inglês
Izdano: Fondazione Ferrata Storti 2019
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604655/
https://ncbi.nlm.nih.gov/pubmed/33131251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.226068
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