Modifying ADAMTS13 to modulate binding of pathogenic autoantibodies of patients with acquired thrombotic thrombocytopenic purpura

Antibodies that develop in patients with immune thrombotic thrombocytopenic purpura commonly target the spacer epitope R568/F592/R660/Y661/Y665 (RFRYY) of ADAMTS13 (a disintegrin and metalloproteinase with a thrombospondin type 1 motif, member 13). In this study we present a detailed contribution of...

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Gepubliceerd in:Haematologica
Hoofdauteurs: Graça, Nuno A. G., Ercig, Bogac, Pereira, Leydi Carolina Velásquez, Kangro, Kadri, Kaijen, Paul, Nicolaes, Gerry A. F., Veyradier, Agnès, Coppo, Paul, Vanhoorelbeke, Karen, Männik, Andres, Voorberg, Jan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Fondazione Ferrata Storti 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604655/
https://ncbi.nlm.nih.gov/pubmed/33131251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.226068
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