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Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats
The pharmacokinetics (PK) of prednisolone (PNL) exhibit nonlinearity related to plasma protein binding, tissue binding, metabolic interconversion with prednisone (PN), and renal elimination. Blood and 11 tissues were collected from male Wistar rats after steady-state (SS) infusion and after subcutan...
সংরক্ষণ করুন:
| প্রকাশিত: | J Pharmacol Exp Ther |
|---|---|
| প্রধান লেখক: | , , , |
| বিন্যাস: | Artigo |
| ভাষা: | Inglês |
| প্রকাশিত: |
The American Society for Pharmacology and Experimental Therapeutics
2020
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| বিষয়গুলি: | |
| অনলাইন ব্যবহার করুন: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7604337/ https://ncbi.nlm.nih.gov/pubmed/32883831 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000191 |
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