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Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats

The pharmacokinetics (PK) of prednisolone (PNL) exhibit nonlinearity related to plasma protein binding, tissue binding, metabolic interconversion with prednisone (PN), and renal elimination. Blood and 11 tissues were collected from male Wistar rats after steady-state (SS) infusion and after subcutan...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Li, Xiaonan, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7604337/
https://ncbi.nlm.nih.gov/pubmed/32883831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.120.000191
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