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Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models

Tumor necrosis factor-α (TNF-α) is a soluble cytokine and target of specific monoclonal antibodies (mAbs) and other biologic agents used in the treatment of inflammatory diseases. These biologics exert their pharmacological effects through binding and neutralizing TNF-α, and thus they prevent TNF-α...

詳細記述

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書誌詳細
出版年:Drug Metab Dispos
主要な著者: Chen, Xi, DuBois, Debra C., Almon, Richard R., Jusko, William J.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469399/
https://ncbi.nlm.nih.gov/pubmed/28411279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074799
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