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Characterization and Interspecies Scaling of rhTNF-α Pharmacokinetics with Minimal Physiologically Based Pharmacokinetic Models

Tumor necrosis factor-α (TNF-α) is a soluble cytokine and target of specific monoclonal antibodies (mAbs) and other biologic agents used in the treatment of inflammatory diseases. These biologics exert their pharmacological effects through binding and neutralizing TNF-α, and thus they prevent TNF-α...

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發表在:Drug Metab Dispos
Main Authors: Chen, Xi, DuBois, Debra C., Almon, Richard R., Jusko, William J.
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5469399/
https://ncbi.nlm.nih.gov/pubmed/28411279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.116.074799
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