Physiologically Based Pharmacokinetics of Dexamethasone in Rats

Blood and multitissue concentration-time profiles for dexamethasone (DEX), a synthetic corticosteroid, were measured in male rats after subcutaneous bolus and infusion dosing. A physiologically based pharmacokinetics (PBPK) model was applied for 12 measured tissues. Tissue partition coefficients (K(...

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Detaylı Bibliyografya
Yayımlandı:Drug Metab Dispos
Asıl Yazarlar: Song, Dawei, Sun, Le, DuBois, Debra C., Almon, Richard R., Meng, Shengnan, Jusko, William J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448200/
https://ncbi.nlm.nih.gov/pubmed/32601175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.091017
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