Physiologically Based Pharmacokinetics of Dexamethasone in Rats

Blood and multitissue concentration-time profiles for dexamethasone (DEX), a synthetic corticosteroid, were measured in male rats after subcutaneous bolus and infusion dosing. A physiologically based pharmacokinetics (PBPK) model was applied for 12 measured tissues. Tissue partition coefficients (K(...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Drug Metab Dispos
Hlavní autoři: Song, Dawei, Sun, Le, DuBois, Debra C., Almon, Richard R., Meng, Shengnan, Jusko, William J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Pharmacology and Experimental Therapeutics 2020
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7448200/
https://ncbi.nlm.nih.gov/pubmed/32601175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.120.091017
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky