Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part II: Sex Differences in Methylprednisolone Pharmacokinetics and Corticosterone Suppression

Methylprednisolone (MPL), a corticosteroid of intermediate potency, remains an important immunomodulatory agent for autoimmune diseases. Although sex differences in corticosteroid pharmacokinetics/pharmacodynamics (PK/PD) have been documented in humans, comprehensive preclinical assessments of such...

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Bibliographische Detailangaben
Veröffentlicht in:J Pharmacol Exp Ther
Hauptverfasser: Ayyar, Vivaswath S., DuBois, Debra C., Nakamura, Toshimichi, Almon, Richard R., Jusko, William J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2019
Schlagworte:
Metabolism, Transport, and Pharmacogenomics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7184193/
https://ncbi.nlm.nih.gov/pubmed/31197019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.257527
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