Modeling Corticosteroid Pharmacokinetics and Pharmacodynamics, Part III: Estrous Cycle and Estrogen Receptor–Dependent Antagonism of Glucocorticoid-Induced Leucine Zipper (GILZ) Enhancement by Corticosteroids

Our previous report examined the pharmacokinetics (PK) of methylprednisolone (MPL) and adrenal suppression after a 50 mg/kg IM bolus in male and female rats, and we described in detail the development of a minimal physiologically based pharmacokinetic/pharmacodynamic (mPBPK/PD) model. In continuatio...

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Dades bibliogràfiques
Publicat a:J Pharmacol Exp Ther
Autors principals: Ayyar, Vivaswath S., DuBois, Debra C., Almon, Richard R., Jusko, William J.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2019
Matèries:
Metabolism, Transport, and Pharmacogenomics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6658921/
https://ncbi.nlm.nih.gov/pubmed/31197018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.119.257543
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