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Pharmacokinetic/Pharmacodynamic Modeling of Corticosterone Suppression and Lymphocytopenia by Methylprednisolone in Rats

Adrenal suppression and lymphocytopenia are commonly monitored pharmacological responses during systemic exposure to exogenously administered corticosteroids. The pharmacodynamics of plasma corticosterone (CS) and blood lymphocytes were investigated in 60 normal rats which received either 50 mg/kg m...

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Detalhes bibliográficos
Main Authors: Yao, Zhenling, Dubois, Debra C., Almon, Richard R., Jusko, William J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726057/
https://ncbi.nlm.nih.gov/pubmed/17828751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.21167
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