Pharmacokinetic/Pharmacodynamic Modeling of Methylprednisolone Effects on iNOS mRNA Expression and Nitric Oxide During LPS-Induced Inflammation in Rats

PURPOSE: Increased expression of inducible nitric oxide synthase (iNOS) resulting in nitric oxide elevation represents an important component of inflammatory responses. We assess the effects of methylprednisolone (MPL) on these processes during endotoxin-induced acute inflammation and provide a mech...

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Main Authors: Sukumaran, Siddharth, Lepist, Eve-Irene, DuBois, Debra C., Almon, Richard R., Jusko, William J.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400266/
https://ncbi.nlm.nih.gov/pubmed/22422321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-012-0733-5
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