Pharmacodynamic Modeling of Acute and Chronic Effects of Methylprednisolone on Hepatic Urea Cycle Genes in Rats

Corticosteroids (CS) regulate many enzymes at both mRNA and protein levels. This study used microarrays to broadly assess regulation of various genes related to the greater urea cycle and employs pharmacokinetic/pharmacodynamic (PK/PD) modeling to quantitatively analyze and compare the temporal prof...

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Bibliografiske detaljer
Main Authors: Hazra, Anasuya, DuBois, Debra C., Almon, Richard R., Snyder, Grayson H., Jusko, William J.
Format: Artigo
Sprog:Inglês
Udgivet: Libertas Academica 2008
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733100/
https://ncbi.nlm.nih.gov/pubmed/19787073
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