Efficacy of HDAC Inhibitors Belinostat and Panobinostat against Cisplatin-Sensitive and Cisplatin-Resistant Testicular Germ Cell Tumors

SIMPLE SUMMARY: There is a need for novel treatment options for patients with testicular germ cell tumors, especially for those that are resistant to standard chemotherapy, who show poor prognosis. In this work, we test two compounds that inhibit epigenetic enzymes called histone deacetylases—belino...

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Dettagli Bibliografici
Pubblicato in:Cancers (Basel)
Autori principali: Lobo, João, Guimarães-Teixeira, Catarina, Barros-Silva, Daniela, Miranda-Gonçalves, Vera, Camilo, Vânia, Guimarães, Rita, Cantante, Mariana, Braga, Isaac, Maurício, Joaquina, Oing, Christoph, Honecker, Friedemann, Nettersheim, Daniel, Looijenga, Leendert H. J., Henrique, Rui, Jerónimo, Carmen
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7601457/
https://ncbi.nlm.nih.gov/pubmed/33050470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12102903
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