A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response

CD8 T cells provide limited protection against Mycobacterium tuberculosis (Mtb) infection in the mouse model. As Mtb causes chronic infection in mice and humans, we hypothesize that Mtb impairs T cell responses as an immune evasion strategy. TB10.4 is an immunodominant antigen in people, nonhuman pr...

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Vydáno v:PLoS Pathog
Hlavní autoři: Sutiwisesak, Rujapak, Hicks, Nathan D., Boyce, Shayla, Murphy, Kenan C., Papavinasasundaram, Kadamba, Carpenter, Stephen M., Boucau, Julie, Joshi, Neelambari, Le Gall, Sylvie, Fortune, Sarah M., Sassetti, Christopher M., Behar, Samuel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7597557/
https://ncbi.nlm.nih.gov/pubmed/33075106
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009000
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