Mycobacterium tuberculosis EsxH inhibits ESCRT-dependent CD4(+) T-cell activation

Mycobacterium tuberculosis (Mtb) establishes a persistent infection, despite inducing antigen-specific T-cell responses. Although T cells arrive at the site of infection, they do not provide sterilizing immunity. The molecular basis of how Mtb impairs T-cell function is not clear. Mtb has been repor...

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Bibliographic Details
Published in:Nat Microbiol
Main Authors: Portal-Celhay, Cynthia, Tufariello, JoAnn M., Srivastava, Smita, Zahra, Aleena, Klevorn, Thais, Grace, Patricia S., Mehra, Alka, Park, Heidi S., Ernst, Joel D., Jacobs, William R., Philips, Jennifer A.
Format: Artigo
Language:Inglês
Published: 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5453184/
https://ncbi.nlm.nih.gov/pubmed/27918526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmicrobiol.2016.232
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