Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures

ABSTRACT Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing environments, despite its genome’s apparent stability. Recently, phase variation through indel formation in homopolymeric tracts (HT) has emerged as a potentially important mechanism promoting adapt...

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Auteurs principaux:	Michael J. Luna, Peter O. Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S. Shell, Thomas R. Ioerger, Sarah M. Fortune, Maha R. Farhat, Christopher M. Sassetti
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology 2025-03-01
Collection:	mBio
Sujets:	tuberculosis bacterial genetics phase variation
Accès en ligne:	https://journals.asm.org/doi/10.1128/mbio.03762-24
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