Frequently arising ESX-1-associated phase variants influence Mycobacterium tuberculosis fitness in the presence of host and antibiotic pressures

ABSTRACT Mycobacterium tuberculosis (Mtb) exhibits an impressive ability to adapt to rapidly changing environments, despite its genome’s apparent stability. Recently, phase variation through indel formation in homopolymeric tracts (HT) has emerged as a potentially important mechanism promoting adapt...

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Main Authors: Michael J. Luna, Peter O. Oluoch, Jiazheng Miao, Peter Culviner, Kadamba Papavinasasundaram, Eleni Jaecklein, Scarlet S. Shell, Thomas R. Ioerger, Sarah M. Fortune, Maha R. Farhat, Christopher M. Sassetti
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2025-03-01
Series:mBio
Assuntos:
tuberculosis
bacterial genetics
phase variation
Acceso en liña:https://journals.asm.org/doi/10.1128/mbio.03762-24
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