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β-Catenin regulates tumor-derived PD-L1
In this issue of JEM, Du et al. (https://doi.org/10.1084/jem.20191115) report that enhancement of the β-catenin signaling by Wnt or EGF treatment increases the expression of PD-L1 in an AKT and β-catenin–dependent manner, and blocking the AKT pathway synergizes with anti–PD-1 in a glioblastoma model...
Shranjeno v:
| izdano v: | J Exp Med |
|---|---|
| Main Authors: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Rockefeller University Press
2020
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7596827/ https://ncbi.nlm.nih.gov/pubmed/32860048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20200684 |
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