Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC

OBJECTIVE: In cartilage, the osteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC, and with differential methylation of PLEC CpG dinucleotides, forming eQTLs and mQTLs respectively. This implies that methylation links chondroc...

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Bibliographic Details
Published in:Osteoarthritis Cartilage
Main Authors: Sorial, A.K., Hofer, I.M.J., Tselepi, M., Cheung, K., Parker, E., Deehan, D.J., Rice, S.J., Loughlin, J.
Format: Artigo
Language:Inglês
Published: W.B. Saunders For The Osteoarthritis Research Society 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594932/
https://ncbi.nlm.nih.gov/pubmed/32580029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2020.06.001
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