Prioritization of PLEC and GRINA as Osteoarthritis Risk Genes Through the Identification and Characterization of Novel Methylation Quantitative Trait Loci

OBJECTIVE: To identify methylation quantitative trait loci (mQTLs) correlating with osteoarthritis (OA) risk alleles and to undertake mechanistic characterization as a means of target gene prioritization. METHODS: We used genome‐wide genotyping and cartilage DNA methylation array data in a discovery...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Rice, Sarah J., Tselepi, Maria, Sorial, Antony K., Aubourg, Guillaume, Shepherd, Colin, Almarza, David, Skelton, Andrew J., Pangou, Ioanna, Deehan, David, Reynard, Louise N., Loughlin, John
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Osteoarthritis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6790675/
https://ncbi.nlm.nih.gov/pubmed/30730609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40849
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