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Identification of a novel, methylation-dependent, RUNX2 regulatory region associated with osteoarthritis risk

Osteoarthritis (OA) is a common, multifactorial and polygenic skeletal disease that, in its severest form, requires joint replacement surgery to restore mobility and to relieve chronic pain. Using tissues from the articulating joints of 260 patients with OA and a range of in vitro experiments, inclu...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Rice, Sarah J, Aubourg, Guillaume, Sorial, Antony K, Almarza, David, Tselepi, Maria, Deehan, David J, Reynard, Louise N, Loughlin, John
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6140783/
https://ncbi.nlm.nih.gov/pubmed/30010910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddy257
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