Multi-tissue epigenetic analysis of the osteoarthritis susceptibility locus mapping to the plectin gene PLEC

OBJECTIVE: In cartilage, the osteoarthritis (OA) associated single nucleotide polymorphism (SNP) rs11780978 correlates with differential expression of PLEC, and with differential methylation of PLEC CpG dinucleotides, forming eQTLs and mQTLs respectively. This implies that methylation links chondroc...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Osteoarthritis Cartilage
Prif Awduron: Sorial, A.K., Hofer, I.M.J., Tselepi, M., Cheung, K., Parker, E., Deehan, D.J., Rice, S.J., Loughlin, J.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: W.B. Saunders For The Osteoarthritis Research Society 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7594932/
https://ncbi.nlm.nih.gov/pubmed/32580029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.joca.2020.06.001
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