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Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity
Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH(4)) remains under investigation. Male Sprague Dawley rats (n = 72) were randomly allocated to recei...
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| Gepubliceerd in: | Brain Sci |
|---|---|
| Hoofdauteurs: | , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
MDPI
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7589689/ https://ncbi.nlm.nih.gov/pubmed/33096612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci10100759 |
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