Chronic Valproic Acid Administration Increases Plasma, Liver, and Brain Ammonia Concentration and Suppresses Glutamine Synthetase Activity

Asymptomatic valproic acid (VPA)-induced hyperammonemia in the absence of liver impairment is fairly common. However, the underlying mechanisms through which VPA causes elevation in plasma ammonia (NH(4)) remains under investigation. Male Sprague Dawley rats (n = 72) were randomly allocated to recei...

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Detaylı Bibliyografya
Yayımlandı:Brain Sci
Asıl Yazarlar: Badawy, Abdelnaser A., Elghaba, Rasha, Soliman, Mohamed, Hussein, Abdelaziz M., AlSadrah, Sana A., Awadalla, Amira, Abulseoud, Osama A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: MDPI 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589689/
https://ncbi.nlm.nih.gov/pubmed/33096612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/brainsci10100759
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