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Paracellular bicarbonate flux across human cystic fibrosis airway epithelia tempers changes in airway surface liquid pH

KEY POINTS: Cl(−) and HCO(3) (−) had similar paracellular permeabilities in human airway epithelia. P(Cl)/P(Na) of airway epithelia was unaltered by pH 7.4 vs. pH 6.0 solutions. Under basal conditions, calculated paracellular HCO(3) (−) flux was secretory. Cytokines that increased airway surface liq...

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Publicat a:J Physiol
Autors principals: Thornell, Ian M., Rehman, Tayyab, Pezzulo, Alejandro A., Welsh, Michael J.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589346/
https://ncbi.nlm.nih.gov/pubmed/32627187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP280120
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