Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia

Airway surface dehydration is a pathological feature of cystic fibrosis (CF) lung disease. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated Cl(−) channel controlled in part by the adenosine A(2B) receptor. An alternative CFTR-independent mechanis...

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Bibliographic Details
Published in:Am J Physiol Lung Cell Mol Physiol
Main Authors: van Heusden, Catharina, Button, Brian, Anderson, Wayne H., Ceppe, Agathe, Morton, Lisa C., O’Neal, Wanda K., Dang, Hong, Alexis, Neil E., Donaldson, Scott, Stephan, Holger, Boucher, Richard C., Lazarowski, Eduardo R.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052677/
https://ncbi.nlm.nih.gov/pubmed/31800264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00449.2019
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