Inhibition of ATP hydrolysis restores airway surface liquid production in cystic fibrosis airway epithelia

Airway surface dehydration is a pathological feature of cystic fibrosis (CF) lung disease. CF is caused by mutations in the CF transmembrane conductance regulator (CFTR), a cyclic AMP-regulated Cl(−) channel controlled in part by the adenosine A(2B) receptor. An alternative CFTR-independent mechanis...

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Detalhes bibliográficos
Publicado no:Am J Physiol Lung Cell Mol Physiol
Main Authors: van Heusden, Catharina, Button, Brian, Anderson, Wayne H., Ceppe, Agathe, Morton, Lisa C., O’Neal, Wanda K., Dang, Hong, Alexis, Neil E., Donaldson, Scott, Stephan, Holger, Boucher, Richard C., Lazarowski, Eduardo R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052677/
https://ncbi.nlm.nih.gov/pubmed/31800264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00449.2019
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