Synthesis and Pharmacological Evaluation of Fluorinated Quinoxaline‐Based κ‐Opioid Receptor (KOR) Agonists Designed for PET Studies

κ‐Opioid receptors (KORs) play a predominant role in pain alleviation, itching skin diseases, depression and neurodegenerative disorders such as multiple sclerosis. Therefore, imaging of KOR by a fluorinated PET tracer was envisaged. Two strategies were followed to introduce a F atom into the very p...

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Publicado en:ChemMedChem
Main Authors: Tangherlini, Giovanni, Börgel, Frederik, Schepmann, Dirk, Slocum, Samuel, Che, Tao, Wagner, Stefan, Schwegmann, Katrin, Hermann, Sven, Mykicki, Nadine, Loser, Karin, Wünsch, Bernhard
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7589326/
https://ncbi.nlm.nih.gov/pubmed/33448685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.202000502
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