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Synthesis and Pharmacology of a Novel κ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton

[Image: see text] We designed and synthesized the 1,3,5-trioxazatriquinane derivatives with m-hydroxyphenyl groups. These compounds include the phenethylamine structure within them, which is a common structure observed in morphinan derivatives like morphine. Among the synthesized compounds, (−)-8c w...

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Bibliografische gegevens
Hoofdauteurs: Hirayama, Shigeto, Wada, Naohisa, Nemoto, Toru, Iwai, Takashi, Fujii, Hideaki, Nagase, Hiroshi
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Chemical Society 2014
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137376/
https://ncbi.nlm.nih.gov/pubmed/25147605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5000542
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