APOE2 is associated with longevity independent of Alzheimer’s disease

Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed...

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Bibliografski detalji
Izdano u:eLife
Glavni autori: Shinohara, Mitsuru, Kanekiyo, Takahisa, Tachibana, Masaya, Kurti, Aishe, Shinohara, Motoko, Fu, Yuan, Zhao, Jing, Han, Xianlin, Sullivan, Patrick M, Rebeck, G William, Fryer, John D, Heckman, Michael G, Bu, Guojun
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications, Ltd 2020
Teme:
Medicine
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588231/
https://ncbi.nlm.nih.gov/pubmed/33074098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62199
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