APOE2 is associated with longevity independent of Alzheimer’s disease

Although the ε2 allele of apolipoprotein E (APOE2) benefits longevity, its mechanism is not understood. The protective effects of the APOE2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed...

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Опубликовано в: :eLife
Главные авторы: Shinohara, Mitsuru, Kanekiyo, Takahisa, Tachibana, Masaya, Kurti, Aishe, Shinohara, Motoko, Fu, Yuan, Zhao, Jing, Han, Xianlin, Sullivan, Patrick M, Rebeck, G William, Fryer, John D, Heckman, Michael G, Bu, Guojun
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2020
Предметы:
Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7588231/
https://ncbi.nlm.nih.gov/pubmed/33074098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.62199
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