APOE2 eases cognitive decline during aging: clinical and preclinical evaluations

OBJECTIVE: Apolipoprotein E (apoE), a major cholesterol carrier in the brain, is associated with a strong risk for Alzheimer’s disease. Compared to the risky APOE4 gene allele, the effects of the protective APOE2 gene allele are vastly understudied, and thus, need to be further clarified. METHODS: W...

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Detalhes bibliográficos
Publicado no:Ann Neurol
Main Authors: Shinohara, Mitsuru, Kanekiyo, Takahisa, Yang, Longyu, Linthicum, Duane, Shinohara, Motoko, Fu, Yuan, Price, Laura, Frisch-Daiello, Jessica L., Han, Xianlin, Fryer, John D., Bu, Guojun
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5010530/
https://ncbi.nlm.nih.gov/pubmed/26933942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24628
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