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Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed AT...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Tietze, Andreas, Shi, Yan‐Ni, Kronenwerth, Max, Bode, Helge B.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586950/
https://ncbi.nlm.nih.gov/pubmed/32378773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000176
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