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Nonribosomal Peptides Produced by Minimal and Engineered Synthetases with Terminal Reductase Domains

Nonribosomal peptide synthetases (NRPSs) use terminal reductase domains for 2‐electron reduction of the enzyme‐bound thioester releasing the generated peptides as C‐terminal aldehydes. Herein, we reveal the biosynthesis of a pyrazine that originates from an aldehyde‐generating minimal NRPS termed AT...

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Pubblicato in:Chembiochem
Autori principali: Tietze, Andreas, Shi, Yan‐Ni, Kronenwerth, Max, Bode, Helge B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7586950/
https://ncbi.nlm.nih.gov/pubmed/32378773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.202000176
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