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Nonprocessive [2 + 2]e(-) off-loading reductase domains from mycobacterial nonribosomal peptide synthetases
In mycobacteria, polyketide synthases and nonribosomal peptide synthetases (NRPSs) produce complex lipidic metabolites by using a thio-template mechanism of catalysis. In this study, we demonstrate that off-loading reductase (R) domain of mycobacterial NRPSs performs two consecutive [2 + 2]e(-) redu...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3326462/ https://ncbi.nlm.nih.gov/pubmed/22451903 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118680109 |
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