Nonprocessive [2 + 2]e(-) off-loading reductase domains from mycobacterial nonribosomal peptide synthetases

In mycobacteria, polyketide synthases and nonribosomal peptide synthetases (NRPSs) produce complex lipidic metabolites by using a thio-template mechanism of catalysis. In this study, we demonstrate that off-loading reductase (R) domain of mycobacterial NRPSs performs two consecutive [2 + 2]e(-) redu...

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Autors principals: Chhabra, Arush, Haque, Asfarul S., Pal, Ravi Kant, Goyal, Aneesh, Rai, Rajkishore, Joshi, Seema, Panjikar, Santosh, Pasha, Santosh, Sankaranarayanan, Rajan, Gokhale, Rajesh S.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3326462/
https://ncbi.nlm.nih.gov/pubmed/22451903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1118680109
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