Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A

Balanced rearrangements involving the KMT2A gene, located at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, the mutational landscape and prognostic impact of specific 11q23/KMT2A rearrangements are not fully understood....

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Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Proc Natl Acad Sci U S A
Κύριοι συγγραφείς: Bill, Marius, Mrózek, Krzysztof, Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Walker, Christopher J., Nicolet, Deedra, Papaioannou, Dimitrios, Blachly, James S., Orwick, Shelley, Carroll, Andrew J., Kolitz, Jonathan E., Powell, Bayard L., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: National Academy of Sciences 2020
Θέματα:
Biological Sciences
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584992/
https://ncbi.nlm.nih.gov/pubmed/33020282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014732117
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