Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A

Balanced rearrangements involving the KMT2A gene, located at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, the mutational landscape and prognostic impact of specific 11q23/KMT2A rearrangements are not fully understood....

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Bill, Marius, Mrózek, Krzysztof, Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Walker, Christopher J., Nicolet, Deedra, Papaioannou, Dimitrios, Blachly, James S., Orwick, Shelley, Carroll, Andrew J., Kolitz, Jonathan E., Powell, Bayard L., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584992/
https://ncbi.nlm.nih.gov/pubmed/33020282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014732117
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