Mutational landscape and clinical outcome of patients with de novo acute myeloid leukemia and rearrangements involving 11q23/KMT2A

Balanced rearrangements involving the KMT2A gene, located at 11q23, are among the most frequent chromosome aberrations in acute myeloid leukemia (AML). Because of numerous fusion partners, the mutational landscape and prognostic impact of specific 11q23/KMT2A rearrangements are not fully understood....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bill, Marius, Mrózek, Krzysztof, Kohlschmidt, Jessica, Eisfeld, Ann-Kathrin, Walker, Christopher J., Nicolet, Deedra, Papaioannou, Dimitrios, Blachly, James S., Orwick, Shelley, Carroll, Andrew J., Kolitz, Jonathan E., Powell, Bayard L., Stone, Richard M., de la Chapelle, Albert, Byrd, John C., Bloomfield, Clara D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7584992/
https://ncbi.nlm.nih.gov/pubmed/33020282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2014732117
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