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Design of Potent pan-IAP and Lys-Covalent XIAP selective Inhibitors Using a Thermodynamics Driven Approach
Recently we reported that rapid determination of enthalpy of binding can be achieved for a large number of congeneric agents or in combinatorial libraries, fairly efficiently. We show that using a Thermodynamic Craig plot can be very useful in dissecting the enthalpy and entropy contribution of diff...
Tallennettuna:
| Julkaisussa: | J Med Chem |
|---|---|
| Päätekijät: | , , , , , , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2018
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7583350/ https://ncbi.nlm.nih.gov/pubmed/29940121 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.8b00810 |
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