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The Down-Regulation of Clusterin Expression Enhances the αSynuclein Aggregation Process

Parkinson’s Disease (PD) is a progressive neurodegenerative disease characterized by the presence of proteinaceous aggregates of αSynuclein (αSyn) in the dopaminergic neurons. Chaperones are key components of the proteostasis network that are able to counteract αSyn’s aggregation, as well as its tox...

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Detalles Bibliográficos
Publicado en:Int J Mol Sci
Main Authors: Lenzi, Chiara, Ramazzina, Ileana, Russo, Isabella, Filippini, Alice, Bettuzzi, Saverio, Rizzi, Federica
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582711/
https://ncbi.nlm.nih.gov/pubmed/33003328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197181
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