EGCG antagonizes Bortezomib cytotoxicity in prostate cancer cells by an autophagic mechanism

The proteasome inhibitors Bortezomib (BZM) and MG132 trigger cancer cell death via induction of endoplasmic reticulum (ER) stress and unfolded protein response. Epigallocatechin gallate (EGCG), the most bioactive green tea polyphenol, is known to display strong anticancer properties as it inhibits p...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Modernelli, Alice, Naponelli, Valeria, Giovanna Troglio, Maria, Bonacini, Martina, Ramazzina, Ileana, Bettuzzi, Saverio, Rizzi, Federica
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4607952/
https://ncbi.nlm.nih.gov/pubmed/26471237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep15270
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