The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair enzyme. The berberine derivatives inhibit the Tdp1 enzyme in the low micromolar range; this is the first reported berberine based Tdp1 inhibitor....

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Publicado no:Int J Mol Sci
Main Authors: Gladkova, Elizaveta D., Nechepurenko, Ivan V., Bredikhin, Roman A., Chepanova, Arina A., Zakharenko, Alexandra L., Luzina, Olga A., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Mamontova, Evgeniya M., Anarbaev, Rashid O., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582571/
https://ncbi.nlm.nih.gov/pubmed/32998385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197162
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