The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme

A series of berberine and tetrahydroberberine sulfonate derivatives were prepared and tested against the tyrosyl-DNA phosphodiesterase 1 (Tdp1) DNA-repair enzyme. The berberine derivatives inhibit the Tdp1 enzyme in the low micromolar range; this is the first reported berberine based Tdp1 inhibitor....

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Bibliografski detalji
Izdano u:Int J Mol Sci
Glavni autori: Gladkova, Elizaveta D., Nechepurenko, Ivan V., Bredikhin, Roman A., Chepanova, Arina A., Zakharenko, Alexandra L., Luzina, Olga A., Ilina, Ekaterina S., Dyrkheeva, Nadezhda S., Mamontova, Evgeniya M., Anarbaev, Rashid O., Reynisson, Jóhannes, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Format: Artigo
Jezik:Inglês
Izdano: MDPI 2020
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582571/
https://ncbi.nlm.nih.gov/pubmed/32998385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197162
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