Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors

An Important task in the treatment of oncological and neurodegenerative diseases is the search for new inhibitors of DNA repair system enzymes. Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is one of the DNA repair system enzymes involved in the removal of DNA damages caused by topoisomerase I inhibitors....

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Publicado no:Molecules
Main Authors: Salomatina, Oksana V., Popadyuk, Irina I., Zakharenko, Alexandra L., Zakharova, Olga D., Fadeev, Dmitriy S., Komarova, Nina I., Reynisson, Jóhannes, Arabshahi, H. John, Chand, Raina, Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6017735/
https://ncbi.nlm.nih.gov/pubmed/29562592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23030679
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