Promising New Inhibitors of Tyrosyl-DNA Phosphodiesterase I (Tdp 1) Combining 4-Arylcoumarin and Monoterpenoid Moieties as Components of Complex Antitumor Therapy

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is an important DNA repair enzyme in humans, and a current and promising inhibition target for the development of new chemosensitizing agents due to its ability to remove DNA damage caused by topoisomerase 1 (Top1) poisons such as topotecan and irinotecan. Here...

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Publicado no:Int J Mol Sci
Main Authors: Khomenko, Tatyana M., Zakharenko, Alexandra L., Chepanova, Arina A., Ilina, Ekaterina S., Zakharova, Olga D., Kaledin, Vasily I., Nikolin, Valeriy P., Popova, Nelly A., Korchagina, Dina V., Reynisson, Jóhannes, Chand, Raina, Ayine-Tora, Daniel M., Patel, Jinal, Leung, Ivanhoe K. H., Volcho, Konstantin P., Salakhutdinov, Nariman F., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6982354/
https://ncbi.nlm.nih.gov/pubmed/31878088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21010126
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