A Novel Class of Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Contains the Octahydro-2H-chromen-4-ol Scaffold

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that mends topoisomerase 1-mediated DNA damage. Tdp1 is a current inhibition target for the development of improved anticancer treatments, as its inhibition may enhance the therapeutic effect of topoisomerase 1 poisons. Here, we report a...

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Publicado no:Molecules
Main Authors: Li-Zhulanov, Nikolai S., Zakharenko, Alexandra L., Chepanova, Arina A., Patel, Jinal, Zafar, Ayesha, Volcho, Konstantin P., Salakhutdinov, Nariman F., Reynisson, Jóhannes, Leung, Ivanhoe K. H., Lavrik, Olga I.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6222798/
https://ncbi.nlm.nih.gov/pubmed/30261631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules23102468
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