Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes

Uptake transporter organic anion transporting polypeptides (OATPs), efflux transporters (P-gp, BCRP and MRP2) and cytochrome P450 enzymes (CYP450s) are widely expressed in the liver, intestine or kidney. They coordinately work to control drug disposition, termed as “interplay of transporters and enz...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Yang, Yiting, Li, Ping, Zhang, Zexin, Wang, Zhongjian, Liu, Li, Liu, Xiaodong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582433/
https://ncbi.nlm.nih.gov/pubmed/32987693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197023
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