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Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes

Uptake transporter organic anion transporting polypeptides (OATPs), efflux transporters (P-gp, BCRP and MRP2) and cytochrome P450 enzymes (CYP450s) are widely expressed in the liver, intestine or kidney. They coordinately work to control drug disposition, termed as “interplay of transporters and enz...

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Publicat a:Int J Mol Sci
Autors principals: Yang, Yiting, Li, Ping, Zhang, Zexin, Wang, Zhongjian, Liu, Li, Liu, Xiaodong
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7582433/
https://ncbi.nlm.nih.gov/pubmed/32987693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21197023
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