Mechanism-Based Pharmacokinetic Modeling to Evaluate Transporter-Enzyme Interplay in Drug Interactions and Pharmacogenetics of Glyburide

The purpose of this study is to characterize the involvement of hepato-biliary transport and cytochrome-P450 (CYP)-mediated metabolism in the disposition of glyburide and predict its pharmacokinetic variability due to drug interactions and genetic variations. Comprehensive in vitro studies suggested...

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Main Authors: Varma, Manthena V. S., Scialis, Renato J., Lin, Jian, Bi, Yi-An, Rotter, Charles J., Goosen, Theunis C., Yang, Xin
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4070267/
https://ncbi.nlm.nih.gov/pubmed/24839071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-014-9614-7
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