A Whole-Body Physiologically Based Pharmacokinetic Model Characterizing Interplay of OCTs and MATEs in Intestine, Liver and Kidney to Predict Drug-Drug Interactions of Metformin with Perpetrators

Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs). Hepatic OCT1, intestinal OCT3, renal OCT2 on tubule basolateral membrane, and MATE1/2-K on tub...

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Publicado en:Pharmaceutics
Main Authors: Yang, Yiting, Zhang, Zexin, Li, Ping, Kong, Weimin, Liu, Xiaodong, Liu, Li
Formato: Artigo
Idioma:Inglês
Publicado: MDPI 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8151202/
https://ncbi.nlm.nih.gov/pubmed/34064886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics13050698
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