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Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches

Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have highlighted that these mutations reduce protein affinities within the RNA polymerase comple...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Portelli, Stephanie, Myung, Yoochan, Furnham, Nicholas, Vedithi, Sundeep Chaitanya, Pires, Douglas E. V., Ascher, David B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7581776/
https://ncbi.nlm.nih.gov/pubmed/33093532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74648-y
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