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Prediction of rifampicin resistance beyond the RRDR using structure-based machine learning approaches
Rifampicin resistance is a major therapeutic challenge, particularly in tuberculosis, leprosy, P. aeruginosa and S. aureus infections, where it develops via missense mutations in gene rpoB. Previously we have highlighted that these mutations reduce protein affinities within the RNA polymerase comple...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7581776/ https://ncbi.nlm.nih.gov/pubmed/33093532 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-74648-y |
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